year 21, Issue 82 (5-2022)
J. Med. Plants 2022, 21(82): 93-110 |
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Research code: 8864
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Dabaghian F, Azadi A, Zarshenas M M. Design, reformulation, and standardization of a traditional-based memory enhancer herbal preparation originated from Persian medicine. J. Med. Plants 2022; 21 (82) :93-110
URL: http://jmp.ir/article-1-3307-en.html
URL: http://jmp.ir/article-1-3307-en.html
1- Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran and Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3- Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran , zarm@sums.ac.ir
2- Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3- Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran , zarm@sums.ac.ir
Abstract: (1798 Views)
Background: Alzheimer’s disease (AD) is the most common type of dementia that has been cited in traditional Persian medicine (TPM) manuscripts under the heading "Farāmūshkārī", "Fesād-e-Zekr" and "Nesiān". Since AD is a significant challenge for health professionals, searching for natural and effective compounds is crucial. Objective: Given the importance of AD, this study has provided a standardized plant-based tablet based on TPM. Methods: Related preparations were extracted from leading pharmaceutical manuscripts of TPM. Out of 127 gathered compound formulations, a preparation containing Bunium persicum (Boiss.) B.Fedtsch. (Persian cumin) and Piper nigrum L. (black pepper) was selected from the Canon of Medicine of Avicenna. After evaluating various excipients for tablet preparation, the proportions of Persian cumin (40 %), black pepper (40 %), hydroxypropyl methylcellulose (HPMC), and polyvinylpyrrolidone (PVP) as solution binder (20 %) were chosen. The final formulation was undergone through ethanol and dichloromethane and essential oil extractions to prepare for HPTLC fingerprints and GC assessments, respectively. The total alkaloid in the tablet's ethanol extract was also determined via spectrophotometry. Results: The final tablet was standardized via GC based on trans-caryophyllene (29.22 %) and g-terpinene (17.72 %). Each tablet contains an average of 0.041 mg of trans-caryophyllene and 0.018 mg of g-terpinene. The amount of the total alkaloid in each tablet was determined 0.06 mg, equivalent to atropine. Conclusion: This prepared simple natural formulation can be considered a traditional-based product to be evaluated clinically and presented as a memory enhancer supplement.
Keywords: Alzheimer's disease, Tablet, Bunium persicum, Piper nigrum, Standardization, Traditional medicine
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2022/03/28 | Accepted: 2022/05/27 | Published: 2022/05/31
Received: 2022/03/28 | Accepted: 2022/05/27 | Published: 2022/05/31
References
1. Dubois B, Epelbaum S, Santos A, Di Stefano F, Julian A, Michon A, Sarazin M and Hampel H. Alzheimer disease: from biomarkers to diagnosis. Rev. Neurol. 2013; 169(10): 744-751. [DOI:10.1016/j.neurol.2013.07.016]
2. Alzheimer's Association, Thies W, Bleiler L. 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013; 9(2): 208-245. [DOI:10.1016/j.jalz.2013.02.003]
3. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W and Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013; 9(1): 63-75. e62. [DOI:10.1016/j.jalz.2012.11.007]
4. Mangialasche F, Solomon A, Winblad B, Mecocci P and Kivipelto M. Alzheimer's disease: clinical trials and drug development. Lancet Neurol. 2010; 9(7): 702-716. [DOI:10.1016/S1474-4422(10)70119-8]
5. Wimo A, Jönsson L, Bond J, Prince M, Winblad B and International AD. The worldwide economic impact of dementia 2010. Alzheimers Dement. 2013; 9(1): 1-11. [DOI:10.1016/j.jalz.2012.11.006]
6. Francis PT. The interplay of neurotransmitters in Alzheimer's disease. CNS Spectr. 2005; 10(S18): 6-9. [DOI:10.1017/S1092852900014164]
7. Garcia-Alloza M, Zaldua N, Diez-Ariza M, Marcos B, Lasheras B, Javier Gil-Bea F and Ramirez MJ. Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J. Neuropathol. Exp. Neurol. 2006; 65(11): 1074-1081. [DOI:10.1097/01.jnen.0000240469.20167.89]
8. Heinrich M and Teoh HL. Galanthamine from snowdrop-the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J. Ethnopharmacol. 2004; 92(2-3): 147-162. [DOI:10.1016/j.jep.2004.02.012]
9. Galimberti D and Scarpini E. Disease-modifying treatments for Alzheimer's disease. Ther. Adv. Neurol. Disord. 2011; 4(4): 203-216. [DOI:10.1177/1756285611404470]
10. Perry G, Cash AD and Smith MA. Alzheimer disease and oxidative stress. J. Biomed. Biotechnol. 2002; 2(3): 120-123. [DOI:10.1155/S1110724302203010]
11. Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA and Perry G. Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Rev. Med. Chem. 2008; 8(13): 1395-1406. [DOI:10.2174/138955708786369582]
12. Costa N, Derumeaux H, Rapp T, Garnault V, Ferlicoq L, Gillette S, Andrieu S, Vellas B, Lamure M and Grand A. Methodological considerations in cost of illness studies on Alzheimer disease. Health Econ. Rev. 2012; 2(1): 18. [DOI:10.1186/2191-1991-2-18]
13. Margolin RA, Araujo JA, Sheinerman K and Van Epps D. P4‐280: Maximizing the potential of small companies in Alzheimer's disease research: Challenges and opportunities. Alzheimers Dement. 2015; 11(7S_Part_19): P893-P893. [DOI:10.1016/j.jalz.2015.08.110]
14. Yang M, Xu DD, Zhang Y, Liu X, Hoeven R and Cho WCS. A systematic review on natural medicines for the prevention and treatment of Alzheimer's disease with meta-analyses of intervention effect of ginkgo. Am. J. Chin. Med. 2014; 42(03): 505-521. [DOI:10.1142/S0192415X14500335]
15. Adhami HR, Farsam H and Krenn L. Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition. Phytother. Res. 2011; 25(8): 1148-1152. [DOI:10.1002/ptr.3409]
16. Hosseinkhani A, Sahragard A, Namdari A and Zarshenas M. Botanical sources for Alzheimer's: A review on reports from traditional Persian medicine. Am. J. Alzheimers Dis. Other Demen. 2017; 32(7): 429-437. [DOI:10.1177/1533317517717013]
17. Jamshidi AH, Eghbalian F, Mahroozade S, Mohammadi Kenari H, Ghobadi A and Yousefsani BS. Recommended natural products in Alzheimer's disease based on traditional Persian medicine. J. Med. Plant. 2020; 19(75): 17-29.
18. Yassin N, El-Shenawy S, Mahdy KA, Gouda N, Marrie A, Farrag A and Ibrahim B. Effect of Boswellia serrata on Alzheimer's disease induced in rats. J. Arab Soc. Med. Res. 2013; 8(1): 1-11.
19. Teymuori M, Yegdaneh A and Rabbani M. Effects of Piper nigrum fruit and Cinnamum zeylanicum bark alcoholic extracts, alone and in combination, on scopolamine-induced memory impairment in mice. Res. Pharm. Sci. 2021; 16(5): 474. [DOI:10.4103/1735-5362.323914]
20. Saenghong N, Wattanathorn J, Muchimapura S, Tongun T, Piyavhatkul N, Banchonglikitkul C and Kajsongkram T. Zingiber officinale improves cognitive function of the middle-aged healthy women. Evid. Based Complement. Alternat. Med. 2012; 2012. [DOI:10.1155/2012/383062]
21. Homayounpour P, Shariatifar N and Alizadeh‐Sani M. Development of nanochitosan‐based active packaging films containing free and nanoliposome caraway (Carum carvi L) seed extract. Food Sci. Nutr. 2021; 9(1): 553-563. [DOI:10.1002/fsn3.2025]
22. Yusif RM, Abu Hashim II, Mohamed EA and Badria FA-E. Gastroretentive matrix tablets of boswellia oleogum resin: preparation, optimization, in vitro evaluation, and cytoprotective effect on indomethacin-induced gastric ulcer in rabbits. AAPS Pharm. Sci. Tech. 2016; 17(2): 328-338. [DOI:10.1208/s12249-015-0351-8]
23. Shirazi M.H, Qarabadin-e-Kabir. Tehran: Institute of Medical History, Islamic and Complementary Medicine Studies, Iran University of Medical Sciences Publications; 2007. [In Persian].
24. Heravi MS. Qarabadin-e-salehi. Tehran: Institute of Medical History, Islamic and Complementary Medicine Studies, Iran University of Medical Sciences Publications; 2004. [In Persian].
25. Arzani MA. Qarabadin-e-Ghaderi. Tehran: Institute of Medical History, Islamic and Complementary Medicine Studies, Iran University of Medical Sciences Publications; 2007. [In Persian].
26. Azam Khan M. Qarabadin-e-Azam. Tehran: Institute of Medical History, Islamic and Complementary Medicine Studies, Iran University of Medical Sciences Publications; 2004. [In Persian].
27. Tonekaboni MM. Tohfat-ol-Moeminin. Qom: Nour Publications; 2011. [In Persian].
28. Avicenna. The Canon of Medicine. Vol. 3. Tehran: Soroush Publications; 2013. [In Persian].
29. Dabaghian F, Azadi A, Setooni M and Zarshenas MM. An overview on multi-ingredient memory enhancers and anti-Alzheimer's formulations from traditional Persian pharmacy. Trends in Pharmaceutical Sci. 2017; 3(4): 215-220.
30. Geldart D, Abdullah EC, Hassanpour A, Nwoke LC and Wouters IJ. Characterization of powder flowability using measurement of angle of repose. China Particuology. 2006; 4(3-4): 104-107. [DOI:10.1016/S1672-2515(07)60247-4]
31. British Pharmacopoeia Commission. British Pharmacopoeia 2017. London: TSO; 2017.
32. Adams RP. Identification of essential oil components by gas chromatography/mass spectroscopy. Fourth ed., Carol Stream: Allured publishing corporation; 2007: 544-545.
33. Shamsa F, Monsef H, Ghamooghi R and Verdian R. Spectrophotometric determination of total alkaloids in Peganum harmala L. using bromocresol green. Res. J. Phytochem. 2007; 1(2): 79-82. [DOI:10.3923/rjphyto.2007.79.82]
34. Beutler JA. Natural products as a foundation for drug discovery. Curr. Protoc. Pharmacol. 2009; 46(1): 9-11. [DOI:10.1002/0471141755.ph0911s46]
35. Süntar I. Importance of ethnopharmacological studies in drug discovery: role of medicinal plants. Phytochem. Rev. 2019; 19(5): 1199-1209. [DOI:10.1007/s11101-019-09629-9]
36. Rutebemberwa E, Lubega M, Katureebe SK, Oundo A, Kiweewa F and Mukanga D. Use of traditional medicine for the treatment of diabetes in Eastern Uganda: a qualitative exploration of reasons for choice. BMC Int. Health Hum. Rights. 2013; 13(1): 1. [DOI:10.1186/1472-698X-13-1]
37. Jalali A, Dabaghian F and Zarshenas MM. Alkaloids of Peganum harmala: Anticancer Biomarkers with Promising Outcomes. Curr. Pharm. Des. 2021; 27(2): 185-196. [DOI:10.2174/1381612826666201125103941]
38. Alanis A, Calzada F, Cervantes J, Torres J and Ceballos G. Antibacterial properties of some plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J. Ethnopharmacol. 2005; 100(1-2): 153-157. [DOI:10.1016/j.jep.2005.02.022]
39. Dawid-Pać R. Medicinal plants used in treatment of inflammatory skin diseases. Postepy. Dermatol. Alergol. 2013; 30(3): 170. [DOI:10.5114/pdia.2013.35620]
40. Rojas G, Lévaro J, Tortoriello J and Navarro V. Antimicrobial evaluation of certain plants used in Mexican traditional medicine for the treatment of respiratory diseases. J. Ethnopharmacol. 2001; 74(1): 97-101. [DOI:10.1016/S0378-8741(00)00349-4]
41. Yang Y, Islam MS, Wang J, Li Y and Chen X. Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective. Int. J. Biol. Sci. 2020; 16(10): 1708. [DOI:10.7150/ijbs.45538]
42. Kunle OF, Egharevba HO and Ahmadu PO. Standardization of herbal medicines-A review. Int. J. Biodivers. Conserv. 2012; 4(3): 101-112. [DOI:10.5897/IJBC11.163]
43. Vandana G, Dhar VJ, Anupam S and Rohit D. Facts about standardization of herbal medicine: a review. Chin. J. Integr. Med. 2012; 10(10): 1077-1083. [DOI:10.3736/jcim20121002]
44. Nasab FK and Khosravi AR. Ethnobotanical study of medicinal plants of Sirjan in Kerman Province, Iran. J. Ethnopharmacol. 2014; 154(1): 190-197. [DOI:10.1016/j.jep.2014.04.003]
45. Mandegary A, Arab-Nozari M, Ramiar H and Sharififar F. Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch. J. Ethnopharmacol. 2012; 140(2): 447-451. [DOI:10.1016/j.jep.2012.01.024]
46. Shah Z, Ali T and Shafi S. Phytopharmacological review of Bunium persicum (Boiss) B. fedtsch. Journal of Drug Delivery and Therapeutics. 2019; 9(2): 458-460. [DOI:10.22270/jddt.v9i2.2509]
47. Bukvicki D, Gottardi D, Prasad S and Tyagi AK. The healing effects of spices in chronic diseases. Curr. Med. Chem. 2020; 27(26): 4401-4420. [DOI:10.2174/0929867325666180831145800]
48. Gholamhoseinian A, Moradi M and Sharifi-Far F. Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Res. Pharm. Sci. 2009; 4(2): 105-112.
49. Koppula S, Kopalli SR and Sreemantula S. Adaptogenic and nootropic activities of aqueous extracts of Carum Carvi Linn (Caraway) fruit: An Experimental Study in Wistar Rats. Aust. J. Medical Herbal. 2009; 21(3): 72-78.
50. Nasrollah GD. Indicative Medicinal Plants in Medicine and Industry: Macroscopic and Microscopic Controls. Isfahan: Chaharbagh; 2013: 159-161. [In Persian].
51. Ahmed HH, Salem AM, Sabry GM, Husein AA and Kotob SE. Possible Therapeutic Uses of Salvia triloba and Piper nigrum in Alzheimer's Disease-Induced Rats. J. Med. Food. 2013; 16(5): 437-446. [DOI:10.1089/jmf.2012.0165]
52. Subedee L, Suresh R, Jayanthi M, Kalabharathi H, Satish A and Pushpa V. Preventive role of Indian black pepper in animal models of Alzheimer's disease. J. Clin. Diagn Res. 2015; 9(4): FF01-FF04. [DOI:10.7860/JCDR/2015/8953.5767]
53. Chonpathompikunlert P, Wattanathorn J and Muchimapura S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. Food Chem. Toxicol. 2010; 48(3): 798-802. [DOI:10.1016/j.fct.2009.12.009]
54. Essa MM, Vijayan RK, Castellano-Gonzalez G, Memon MA, Braidy N and Guillemin GJ. Neuroprotective effect of natural products against Alzheimer's disease. Neurochem. Res. 2012; 37(9): 1829-1842. [DOI:10.1007/s11064-012-0799-9]
55. Vurmaz A, Bozkurt F and Akbulut MD. The effect of betaine and piperine on rats with created alzheimer-like dementia by AF64A. Kocatepe Tıp. Dergisi. 2020; 21(2): 183-190. [DOI:10.18229/kocatepetip.579496]
56. Hritcu L, Noumedem JA, Cioanca O, Hancianu M, Kuete V and Mihasan M. Methanolic extract of Piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta (1-42) rat model of Alzheimer's disease. Cell Mol. Neurobiol. 2014; 34(3): 437-449. [DOI:10.1007/s10571-014-0028-y]
57. Mostafa NM, Mostafa AM, Ashour ML, Elhady SS. Neuroprotective effects of black pepper cold-pressed oil on scopolamine-induced oxidative stress and memory impairment in rats. Antioxidants. 2021; 10(12): 1993-2008. [DOI:10.3390/antiox10121993]
58. Cheng Y, Dong Z and Liu S. β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacol. 2014; 94(1-2): 1-12. [DOI:10.1159/000362689]
59. Hu Y, Zeng Z, Wang B and Guo S. Trans-caryophyllene inhibits amyloid β (Aβ) oligomer-induced neuroinflammation in BV-2 microglial cells. Int. Immunopharmacol. 2017; 51: 91-98. [DOI:10.1016/j.intimp.2017.07.009]
60. Wang J, Guo Y and Li GL. Current status of standardization of traditional Chinese medicine in China. Evid. Based Complement. Alternat. Med. 2016; 2016. [DOI:10.1155/2016/9123103]
61. Govindaraghavan S and Sucher NJ. Quality assessment of medicinal herbs and their extracts: Criteria and prerequisites for consistent safety and efficacy of herbal medicines. Epilepsy Behav. 2015; 52: 363-371. [DOI:10.1016/j.yebeh.2015.03.004]
62. Liang Y, Xie P and Chau F. Chromatographic fingerprinting and related chemometric techniques for quality control of traditional Chinese medicines. J. Sep. Sci. 2010; 33(3): 410-421. [DOI:10.1002/jssc.200900653]
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